The two causes I care most about are MAPS and SENS. Effective altruism is close to my heart.
I also support Archive.org & Wikipedia. As well as developers & artists I admire via Patreon/GitHub.
Sublime Fund - Charity that makes philanthropy easy. Donate monthly to multiple charities from one place.
In Support of Super-Rich Philanthropy (2020)
The Giving Pledge - Commitment by the world's wealthiest individuals and families to dedicate the majority of their wealth to giving back.